Sentence examples for the development of an ineffective from inspiring English sources

Predicting which strains of seasonal influenza to include in the annual vaccine is a difficult task, and has on multiple occasions led to the development of an ineffective or partially protective vaccine.

It is therefore necessary to quantify the likelihood of either incorrectly halting the development of an active agent or continuing development of an ineffective agent.

The project described in this paper aims at the development of an intervention program to both prevent and manage these ineffective behaviours among long-term non-psychotic patients who have not benefited from previous treatment, and their key clinicians.

The development of a successful immunotherapy is hampered by an ineffective T-cell repertoire against tumour antigens and the inability of the patient's immune system to overcome tolerance-inducing mechanisms.

Viral isolation of LCDV is difficult, time-consuming and often ineffective; the development of a rapid and specific tool to detect and quantify LCDV is desirable for both diagnosis and pathogenic studies.

Fourth, analyses of HIV informed us early on of ineffective immune responses to it [ 7, 8] and of the enormous antigenic diversity of the virus [ 9], which have been stumbling blocks in the development of a broadly efficacious vaccine.

Ineffective, information transfer therefore directly affect the success of ToC in a practical sense but may also affect the development of a trusting relationship between the client and health professional involved at that point.

Although multiple etiologies contribute to the development of CRS, ineffective sinonasal mucociliary clearance is the common fundamental pathophysiology.

We also found that additional HER2 blockade after the development of lapatinib resistance was ineffective and that PI3K inhibition was essential to overcoming resistance.

Thus, disturbances in the intrinsic as well as extrinsic pathway may enforce the development of autoimmunity because of ineffective elimination of effector lymphocytes during the shutdown of immune responses, a notion already suggested in early studies on lpr mice expressing transgenic Bcl-2.

TM and TI patients are exposed to prolonged tissue hypoxia that can lead to the development of bone marrow expansion, increasingly ineffective erythropoiesis, and increased intestinal iron absorption.