Sentence examples for the development of an aggressive from inspiring English sources

By tying managers at all levels to short-term considerations, they short-circuit the development of an aggressive manufacturing strategy.

Donnarumma et al. showed that in breast cancer, CAF-derived EVs contain three miRNAs (miR-21-5p, -378e, 143-3p) that induce stemness and epithelial mesenchymal transition (EMT) of breast cancer cells, regulating the development of an aggressive cancer phenotype [42].

We used the same approach to test the hypothesis that STAT1 mediates the development of an aggressive pro-lung colonization phenotype as described here.

As such, sustained nuclear FOXO3a expression in breast cancer may culminate in cancer progression and the development of an aggressive phenotype similar to that observed in cytotoxic chemotherapy resistant breast cancer cell models.

To address this question, we used a breast cancer cell model to study the relationship between ACLS4 expression and intramitochondrial AA and its role in the generation of lipooxygenase and cyclooxygenase metabolites and the development of an aggressive cell phenotype.

It can therefore be argued that ACSL4 overexpression might contribute to the development of an aggressive phenotype in breast cancer cells by regulating the production of lipooxygenase and cyclooxygenase metabolites.

Residences conceived in Rose's design philosophy result to the creation of an "environment" instead of the ordinary approach of architecture plus landscape, exhibiting his contribution to the development of a less aggressive architecture, more attentive and integrated to the environment.

Numerous studies have shown that the presence of ACPA and their concentration are associated with the development of a more aggressive disease.

ACPA have a predictive role in rheumatoid arthritis, they are associated with the development of a more aggressive disease, extra-articular manifestations and premature mortality in RA patients; moreover, they are capable of predicting therapeutic response.

Thus, these findings demonstrate that the systemic sensitization to IL13-PE does not predispose mice to the development of a more aggressive form of fibrosis nor does it prevent the intranasal delivery of IL13-PE from exerting a prominent anti-fibrotic effect.

Loss of p53 enhances aerobic glycolysis, resulting in the development of a more aggressive tumor.