Sentence examples similar to the development of a difficult from inspiring English sources

Additionally, obesity results in the development of a difficult-to-control asthma phenotype in which patients experience worse clinical control, poorer quality of life, reduced lung function, poor responses to corticosteroids and more psychosocial symptoms [ 11– 11].

"The recent introduction of targeted tax allowances to promote the development of a range of difficult projects, coupled with the government's ground-breaking commitment to provide certainty on decommissioning tax relief, has prompted global companies and independent businesses alike to take another look at the UK as an investment destination," Mr Webb said.

The development of a vaccine is especially difficult because it will need to counter all four types of virus.

The main drawback of the simulation of application's software using an accurate model of the processor resides in the development of a handwritten simulator which is a difficult and tedious task.

These different objectives make the development of a single measure of quality difficult.

The development of a shape meter is so difficult that it has been monopolized for a long time by Sweden's ABB, Germany's SIEMENS, SUNDWIG, and other international companies [83, 84, 85, 86, 87].

However, the development of a selective BACE1 inhibitor is difficult due to its highly flexible catalytic site and homology to other aspartic proteases, including BACE2 and Cathepsin D (CTSD).

Given the multiplicity of analyses employed in the development of a new instrument it is difficult to derive a priori sample size estimates.

In Swimming pool, several environmental and control variables, directly or indirectly, affect energy consumption and thermal comfort, rendering difficult the development of a mathematical relationship amongst input and output variables.

The feature of rapid diffusivity for some financial innovations is a crucial one, particularly when we consider Collingridge's (1982) concept of the dilemma of control, that is, a situation where, at the early stages of the development of a technological innovation, innovators find it difficult to predict all the social consequences of their actions due to insufficient knowledge or foresight.

Numerous technical efforts have been made to reliably detect and quantify CTC, but the development of a universal assay has proven quite difficult.