Sentence examples for the development of a defined from inspiring English sources

These mutations resulted in the replacement of positive charges with negatively charged residues, allowing the development of a defined structural patch that resembles the one present in the naturally evolved highly crossreactive viral chemokine-binding proteins (vCKBPs 49,50.

In this study we report on the development of a defined system (artificial surface, serum-free medium combination, consistent cell preparation), which promotes the differentiation and long-term survival of rat embryonic cardiomyocytes.

In this work, we demonstrate the development of a defined motoneuron and muscle co-culture system resulting in the formation of NMJs including: 1) a new culture technique, 2) a novel serum-free medium formulation and 3) a synthetic self-assembled monolayer (SAM) substrate N-1 [3- trimethoxysilyl) propyl] diethylenetriamine (DETA).

In order to circumvent this early embryonic lethality and to be able to probe the function of NMD during the development of a defined organ, we crossed the conditional Upf2fl/+ allele onto the Alfp-Cre strain thereby facilitating deletion of UPF2 during liver development.

In 1999 2000 the Ministry of Health and Social Welfare publicly expressed its commitment to the development of a defined basic benefit basket.

However, the development of a defined medium (C. elegans Maintenance Medium (CeMM), [ 2]) lagged far behind the development of C. elegans as a genetic system [ 3].

Here, we describe the development of a genetically defined strain of l-lysine hyperproducing Corynebacterium glutamicum by systems metabolic engineering of the wild type.

Many of the best-known Irish authors lived and worked for long periods in exile, often in England, and this too has contributed to a sense of instability in the development of a canon defined as uniquely Irish.

These findings indicate that Y-27632 is a useful supplement for the development of a chemically defined culture medium for fabrication of stratified epithelial cell grafts for clinical applications for the purpose of developing the culture medium with a lower risk of pathogen transmission that might arise from animal-derived materials.

An additional factor is the development of a clearly defined measurement protocol, which appears lacking in the literature as the study currently employing CBCT as a means of determining root volume loss with maxillary expansion lacks a clearly defined measurement protocol involving incorrectly utilized Hounsfield units with the teeth of interest 'segmented cautiously' [24].

Health risk-based metrics are a useful tool for the development of a clearly defined definition of a heatwave event.