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The lab will focus on the development and activation of T cells for drug-discovery applications.
Recent progress on the function of miRNAs in the development and activation of DCs and their functional relevance to autoimmune diseases are discussed.
Protein tyrosine phosphatase non-receptor 22 (PTPN22) influences the development and activation of lymphocytes, innate cell-mediated immune host defense, formation of tolerance, and regulation of the immune system [[99]].
Early studies indicated that miR-10a could regulate the development and activation of immunocytes by targeting BCL6 and its co-repressor Ncor2, which impacts the stability of the differentiation of Tregs (Takahashi et al., 2012).
RASGRP1 is involved in the development and activation of several immune cell types [36], [37].
Caspase-8 is pointed out to play an essential role in the development and activation of immune cells [15], [16].
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The large family of cytokines, the ILs, promote the development, differentiation and activation of lymphocytes and therefore play an important role in the immune response.
Inactivation of Shh signaling is associated with the defects in vascular development, and activation of Shh signaling causes hypervascularization, however, the precise mechanism governing the vascularogenesis by Shh signaling is still not clear.
Many genes are involved in the development, maintenance, and activation of the neural and muscular tissues that make up the motor unit.
The overexpression of genes associated with RNA metabolism is in agreement with the fact that oocytes store a great amount of RNA to support the processes of fertilization, early embryonic development, and activation of the embryonic genome.
PPARγ (peroxisome proliferator-activated receptor gamma) is the master regulator of adipocyte development, and activation of PPARγ can lead to adipogenesis and obesity.
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