This was done by multiplying the voxel values in the segmented images by the Jacobian determinants from the spatial normalization step.
These were segmented again in normalized space and multiplied (i.e., modulated) by the Jacobian determinants from the normalization step to preserve the volume information in each voxel [ 67].
This is in contrast to a regression model that included the motivational determinants from the original questionnaire (results not shown) that had an R2 of 0.551.
The main determinants from the I-Change Model (attitude, social influences, self-efficacy expectations, intention and behaviour) are addressed in the tailored feedback letters by using theoretical methods that promote changes in these determinants [ 34, 35].
Subsequently, all images were scaled by the Jacobian determinants from the normalization step to preserve initial volumes (Good et al., 2001) and smoothed by convolution with an isotropic Gaussian kernel of 6 mm full-width at half maximum.
The ruralites and urbanites often were the two extremes, with the urbanisers maintaining some of the determinants patterns from ruralites and the de-urbanisers maintaining patterns from urbanites.
Subsequently, a Delphi study among 44 implementation experts (researchers, programme managers, and consultants/advisors) was conducted to achieve consensus on the determinants identified from the literature review.
A full multivariable model (Technical Appendix Table 3) was fitted by using the significant determinants from Table 5 together with the use of antimicrobials and cephalosporins; results from the backward elimination of non-significant terms are presented in Table 6.
The results show that it is relatively easy to separate the educational determinants from each other in order to facilitate subsequent reflection about the strategic action to take.
This results in the loss of cortical attachment of the cell fate determinants from the apical domain, restricting their activity in only the basal ganglion mother cell (GMC).
