Suggestions(2)
Exact(3)
That seems to trigger the desired reprogramming.
Due to the noise inside cell, the cell population showing a common phenotype are heterogeneous; a subset of the cell population that are not completely specified for a phenotypic state can all initiate reprogramming but only a portion of them can complete the desired reprogramming.
The group were able to excise the bacterial backbone from the plasmid as well as the origin of replication and drug resistance genes by taking advantage of the PhiC31-based intramolecular recombination system which cleaves away the undesired bacterial artifacts and degrades them, leaving MC DNA to be purified containing the desired reprogramming factors.
Similar(57)
Consistent with the landscape concept, there are many recipes that can achieve a desired reprogramming.
After validating the crude network dynamics with the observed gene expression behaviour during cell differentiation, we can employ the model to predict the appropriate gene combination for the desired cell reprogramming.
Additionally, the metabolism of host organism was reprogrammed to the desired biochemical product by the clustered regularly interspaced short palindromic repeats interference system, resulted in a final MCFA production of 3.8 g/L.
From the regenerative medicine perspective, in future, new therapies might be designed based on the patient's own cells that are directly reprogrammed into the desired cell types in vitro and in situ.
This implies that all the cells will need to be reprogrammed to the desired phenotype, within a short period of time.
iPSCs could be very useful in modeling diseases and screening drugs, and clarification of the molecular mechanism of reprogramming and cell fate determination is also important to efficiently produce the desired specific type of cells for cell-based replacement therapy.
Conventional methods of genetic reprogramming involve the overexpression of master regulatory transcription factors that control the gene networks corresponding to the desired cell phenotypes.
A major utility of direct reprogramming is the potential of harnessing resident support cells within damaged organs to regenerate lost tissue by converting them into the desired cell type in situ.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com