Sentence examples for the deleterious side from inspiring English sources

The absence of even the slightest compassion or of any commentary about the need for assistance for those who have fallen victim to the deleterious side of free trade is quite revealing and instructive.

The objectives of the current study were to develop novel dual PPARγ/δ agonists without the deleterious side effects associated with full PPARγ agonists.

We found one (compound 9) out of the 23 compounds evaluated, to be the most potent and selective dual PPARγ/δ agonist which did not display the deleterious side effects associated with full PPARγ agonists.

The classical inhibition of the mTOR pathway is effected by rapamycin and its analogous blocking allosterically the catalytic phosphorylation site, avoiding the deleterious side effects induced by ATP-competitive inhibitors.

Thus, the combination of temozolomide or fotemustine with PARP-1 inhibitors in clinical trials (Helleday et al., 2008) or with NF-κB inhibitors (e.g. sulfasalazine, in clinics for inflammatory bowel diseases) may confer potent anti-tumor efficacy and improve the therapeutic index by hypersensitizing melanoma cells to DNA damage while preventing the deleterious side effects.

In all cases, FA-decorated NPs showed superior efficacy as a drug delivery system as compared to DOX-CNPs and native DOX, which suggests that targeting of Y-79 with folic acid may play a pivotal role in increasing the therapeutic efficacy of drugs as well as decreasing the deleterious side effects by considerable reducing the dosage.

The affidavit details how his use of cannabis has allowed him to reduce his use of opiate-based drug oxycodone and has lessened the "deleterious side-effects" he had experienced.

Although the biological mechanisms underlying these deleterious side effects are incompletely understood, radiation exposure triggers an acute inflammatory response that may evolve into chronic inflammation, offering one avenue of investigation.

Consequently, given the possible deleterious side effects of hyperoxia, the current guidelines of the ARDSNetwork and the Surviving Sepsis Campaign recommend using an FiO2 that allows achieving an arterial hemoglobin O2 saturation of 88 95 % at airway plateau pressures and PEEP levels of <30 and 5 20 cmH2O, respectively [15, 17].

Consequently, given the possible deleterious side effects of hyperoxia, the current guidelines of the ARDSNetwork and the Surviving Sepsis Campaign recommend using an FiO2 that allows achieving an arterial hemoglobin O2 saturation of 88 95 % at airway plateau pressures and PEEP levels of <30 and 5 20 cmH2O, respectively [ 15, 17].

Our negative results are consistent with previous data showing that rTMS has a selective effect on abnormal or injured brain circuitry, and the lack of deleterious side effects observed in normal human subjects.