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First, the study design does not allow for the definitive determination of a causal relationship - we can only report observed associations.
Groups of patients with different characteristics such as menopausal and ER status or HER-2 over-expression might be necessary for the definitive determination of classifying patterns in these subsets of patients.
However, SIRS-2 are not used for the definitive determination of malingering or feigned mental disorders, that is to say, there is need for a full evaluation of feigning together with other clinical data.
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Furthermore, Phase II studies rarely predict success in Phase III trials in heart failure and simply prolong the time and increase the cost involved in making a definitive determination of the efficacy and safety of a new treatment, which always requires a large mortality/morbidity trial.
It strikes down New York's procedure and then tells New York not to retry the petitionermerely to have the trial judge hol a hearing on the admissibility of the confession and enter a definitive determination on that issue, as under the Massachusetts rule.
There were no witnesses to the shooting and no definitive determination of which man could be heard yelling for help in the background of a 911 call.
However, the lack of matched normal specimens in this study made it difficult to make definitive determination of the somatic status of the observed mutations.
But the analysts evidently didn't feel that they had any single report that allowed them to make a definitive determination about the nature of the attack.
I am reluctant to make a definitive determination regarding the appropriate remedy because none of the parties developed an argument in favor of a refund, a particular injunction or both or otherwise developed an argument regarding what the court should do in the event that it concludes that § 107(2) is unconstitutional.
"Under the circumstances, the most prudent course the Court sees open to it would be to approve the settlement subject to a condition that it would become final upon a definitive determination in the Citigroup appeal," Marrero wrote in his 34-page decision.
Given the potential protective roles of these proteins, further study is required before a definitive determination of the benefits of normalizing their expression with insulin can be made.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com