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The definition of the protocol is "open", i.e., it is freely available.
Response evaluation was not formally possible in two patients according to the definition of the protocol, in one patient because of disease progression after two administrations and one patient was lost to follow-up after the first paclitaxel administration.
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AQ, CN and MTM contributed equally to the definition of the study protocol, to the data collection, input and analysis and to the manuscript drafting and writing; GC contributed to the definition of the study protocol and to the data collection; CM contributed to the data collection and input; FF contributed to the data analysis.
In Argentina, in the definition of the intervention protocol some physicians involved in the trial requested one ultrasound assessment without medical indication, which was not included [ 1].
CN contributed to the definition of the study protocol, to the data collection, input and analysis and to the manuscript drafting and writing; VM contributed to the data collection, input and analysis and to the manuscript drafting and writing; MTM contributed to the data collection, input and to the manuscript drafting and writing.
The research team would like to thank the RBF4MNH Initiative implementing team of the Reproductive Health Unit of the Malawi Ministry of Health, as well as the support team from Options Consultancy Services for allowing an open dialogue between project implementation and impact evaluation which was vital to the definition of the study protocol and its alignment with the implementation process.
Several performance metrics were developed over the years to evaluate the performance of virtual screening methods and guide the definition of the best protocols.
However, the diagnostic path for many of these patients remains often long and requires high-level expertise: the creation of international registries is highly needed to standardize guidelines about the role of genetics in the diagnosis and expedite the definition of the best treatment protocols.
Indeed, the most challenging issue in geocast protocols is the definition of the ZOR for a given event dissemination.
Solving this difficulty involves two winning assets: the definition of modular protocol architecture and the clever use of the object oriented [23, 24] software techniques in order to design a modular software architecture.
However, such procedure requires the exchange of messages which implies the definition of a protocol for this purpose [16] and the handling of data structures to be stored in the forwarding nodes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com