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Discover LudwigThe phrase "the defining difference" is correct and usable in written English.
It can be used to highlight a key distinction or characteristic that sets something apart from others. Example: "The defining difference between the two products is their durability, which makes one a better choice for outdoor use."
Exact(24)
That's an important, if not the defining, difference.
The defining difference, quite simply, was that Augusta County had slavery, and Franklin County did not.
However, I'm not sure that's the defining difference between then and now.
If you take it from Dawkins, the defining difference is reason, or science.
IT IS, says Tony Blair, the "defining difference" between his government and its Tory predecessors.
The defining difference is that the soldiers will go away and the Taliban will hang around to cut your throat.
Similar(34)
One of the defining differences last weekend was the performance of the two outside-halves, Jonathan Sexton of Leinster and the aforementioned James.
Facebook (almost counterintuitively) is the one that favors an algorithmic approach, and currently it's one of the defining differences between Facebook and G+.
What are the defining differences between stem-like cells from benign tumours and from malignant tumours?
The defining differences can be beneficial for virus replication and survival and may favor the emergence of infectious disease.
The formulation and inclusion of recommendations is one of the defining differences between clinical practice guidelines and other evidence syntheses such as systematic reviews.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com