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The lead programmer receives the data transfers from all sites, confirms the datasets are consistent with expectations, and combines the data from all collaborating sites.
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The analyst gives the checklist to the project manager, who verifies that any PHI identified in the datasets is consistent with all relevant IRB agreements and DUAs.
Although predictions of the cellular protein and mRNA content made from the genome-wide datasets are consistent with available experimental data, the quality of predictions of translational activity can be further evaluated by comparison with published evidence relating to the activity of factors participating in the translational process.
Thus, both microarray datasets are consistent with our prediction that Pbx-Hox motifs in CNEs represent direct regulatory links between Hox genes and their targets during development.
Non-neutral patterns seen in this dataset are consistent with excess slightly deleterious polymorphism within regions and potential selective sweeps for a few sites.
Liu et al. (2008b) also showed that the WINDII and the Arecibo datasets were consistent with the solar flux variation.
The overall phylogenetic relationships as deduced from the concatenated dataset are consistent with the now broadly accepted branching pattern of the mammalian tree [ 1].
First, the increased levels of diversity at the intergenic loci chosen in the current study as compared to the levels of diversity at loci in the compiled dataset are consistent with reduced effects of background selection and genetic hitchhiking in these regions.
Grouping patterns in the whole dataset are consistent with race (first PC, distinguishing accessions that are Phalaris arundinacea from those that are Phalaris caesia), panel (second and third PCs), and geographical origin Eastern Europe vs. North America or Western Europe (fourth PC).
In this way, the expression profiles from these genes in the RNA-Seq dataset are consistent with the results obtained with the array dataset, e.g.: genes HOXA9 and MEIS1 were down regulated in APL in comparison to nk-AML.
The degree of correlation between the cDNA and oligo microarray datasets is consistent with the degrees found in previous analyses [ 19], but further evaluation of variations between the results of this and previous studies in this respect is beyond the scope of this article.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com