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However, if the number of missing data is more than 10%, the data will be evaluated after multiple imputation of the data by a Markov chain Monte Carlo (MCMC) method.
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However, these data will be evaluated by members of the Group that are independent of these involvements.
They explained that doing so "lend[s] strength, objectivity, and credibility to the outcome of the research" because "when investigators own the data and the scientific information that they generate... they are in control of how those data will be evaluated, used and communicated" (Henry and Conrad 2008).
When investigators own the data and the scientific information that they generate through their research efforts, they are in control of how those data will be evaluated, used, and communicated.
The measured data will be evaluated regarding to their temporal correlations in the time and frequency domain.
At 6 weeks after inclusion of these patients the trial's safety data will be evaluated.
Additionally, if deemed necessary, the impact of missing data will be evaluated in sensitivity analysis.
8) With regard to the discussion about the need for power factors, molecular biology experiments (e.g. sequencing, proteomics, pulldowns) often do not have a real power factor or quantification, and it is not clear how the validity of such data will be evaluated (see next point).
The potential impact of missing data will be evaluated in statistical sensitivity analyses.
Furthermore, differences at each trial visit will be estimated along with the 95% confidence limits to assess excursions, and data will be evaluated as total responses during the study period using AUC (calculated by the trapezoidal rule) for the estimated and dose-corrected plasma liraglutide (secondary endpoints).
Parametric data will be evaluated using the Student's t-test.
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