But Black says that the data are corroborated by measurements from the Allegheny telescope, and in at least one case are supported by independent work by Tsevi Mazeh and his colleagues at the Wise Observatory in Israel.
The data are corroborated by the good metabolic stability reported for the structurally similar compound RDEA-806 (figure S2), a non-nucleoside inhibitor of HIV reverse transcriptase and clinical precedent [24], which shares the 2-thio-connector of JMN3-003 but lacks MeV inhibitory activity in our assays (data not shown).
Twenty-six percent of the CD133 knockdown cells were BrdU positive while 70% of the control cells were BrdU positive; these data were corroborated in NCCIT cells (Supplementary Figure 5a).
Thus, in the case of MUC5AC, the microarray data were corroborated by protein expression analyses.
The mRNA data were corroborated by protein levels for BAMBI in Western blots with BAMBI overexpressed in HEK293 cells serving as control for the specificity and position of the BAMBI protein (Figure 1B).
Since it is well known that there is no complete neuronal loss, but still severe neurodegeneration in the striatum and the motor cortex of R6/2 mice, the light microscopical data were corroborated by semithin- and ultrasection analysis (Fig. 5).
Importantly, these data are corroborated by the finding that FasL also inhibited AD-induced expression of PPARγ, adiponectin, and FABP4/aP2 differentiation genes, as documented by qRT-PCR.
These NMR data were corroborated by the results of a biochemical assay showing that the inhibitory activity of F152 is increased by the addition of the methyl moiety on the phenyl ring (IC50 = 105±8.5 µM and 26±2.2 µM for F152 and compound D3, respectively).
Paxilline and penitrem A data were corroborated with the BK peptide inhibitor charybdotoxin (Fig. S1).
These data were corroborated by the myelin SBB staining (Fig. 6I, J), which all together provide evidence that the endotoxin can indeed provoke demyelination, but only in mice that bear a mutation in the Cp gene.
