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The bulk (90%) of the data was set aside for use as an external validation set and was not used or referred to in any way for model building.
The data used in the training stage was randomized to avoid bias, subsequently being divided into 3 independent datasets: 75% of the data was set as the training set, 15% as the testing set, and the remaining 10% was set aside for cross-validation.
For the radioligands used in this study, plotting the integral of C p versus the integral of C b results in a linear function for t > t* (Fig. 2), where t*, after preliminary analysis of the data, was set as the same linearization time as that used to measure V T and DVR (see the "Discussion" section).
PhyloGenie was run using default settings except that the minimum expect "e-value" for the BLAST search of the data was set at 10.
Access to external research groups for downloading the data was set to be carried out through the project management committee (through its former coordinator, Professor Celda from Universidad de Valencia) and the involved partners that gathered and curated these data.
Statistically significance of the data was set at P<0.05, with one asterisk representing 0.01< P<0.05; two asterisks representing 0.001< P<0.01; and three asterisks representing P<0.001.
Similar(52)
In the current dataset, 2.8 % of the data were set to missing values due to low gaze confidence values.
5% of the data were set aside for the calculation of Rfree.
5% of the data were set aside as a test set for calculation of the free R-factor.
The rate of positive interactions in the data were set at 0.3.
Therefore, the threshold for this data was set at P=0.05/4=0.0125.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com