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In the latter case, as a consequence of the different platforms used for miRNA profiling, the data categorisation in the METABRIC collection was done using the percentile threshold identified by ROC curves in the previous analysis.
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Thematic analysis [ 15] was undertaken as the primary means of data categorisation for the purposes of classification, summarisation and tabulation.
The lack of a period effect in the current French analysis, where data categorisation differed from that of previous studies, favoured the artefactual nature of the period effect.
For this potential to be realised we need intelligent strategies for data categorisation and the ability to link sequence data with relevant literature.
Further detail on data categorisation is available on the study website, alongside the full list of included funders and the search keywords used.
In previous research in China we have used combinations of both, but usually where time is short the data coding, categorisation and identification of themes is done manually and in Mandarin, with discussion of important content of themes aided by English summaries [ 18].
We used a classical APC categorical analysis with one-year data categorisation.
In our study, we analysed Italian and reanalysed French BSE data in parallel, with a more appropriate data categorisation and method, in order to characterise and compare BSE trends in both countries, as they experienced different types of BSE epidemics.
The process of thematic analysis involved continually revisiting the data and reviewing the categorisation of data until the researcher was sure that the themes and categories used to summarise and describe the findings were a truthful and accurate reflection of the data.
Researchers combined top-down, thematic coding that was guided by a matrix of socio-technical factors 13 and bottom-up, inductive coding that allowed themes to emerge from the data without prior theoretical categorisation.
The original categorisation of the data would have created 256 such subgroups and made the interpretation too complex.
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