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Substantial evidence exists for the general role of K63-linked ubiquitination in promoting TRAF6-mediated signal transduction, and while the TRAF6 RING finger domain is essential, the dispensability of TRAF6 autoubiquitination opened the possibility that the critical function of the RING domain is unrelated to ubiquitin E3 ligase activity.
The critical function of the genes in these primary metabolic pathways may be constrained in the range of gene expression values that the pathways transcripts can occupy and the more specific definition of their biological activity may enhance our ability to detect this.
This is an important conclusion as many studies assume that RNA granules perform the critical function of the germ plasm.
While investigation of coding sequences can be powerful, significant evidence supports the critical function of the non-coding (and even non-genic) portions of the genome [ 3, 4].
Given the critical function of the ER, it seems likely that cell cycle regulatory mechanisms must exist to ensure inheritance of a fully functional ER during cell division.
Interviews with stakeholders revealed that the critical function of the MSM CBO to authentically represent the community has been partially under-cut by CBOs' financial dependence on other organizations.
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The critical function of this deubiquitinating enzyme in the restriction of TLR signals emphasizes the importance of the regulation of ubiquitin conjugation in innate immune cells.
Convergence on this target by multiple chemophores highlights the critical function of this protein in the parasite.
The downregulation of transcription was also seen for the sac3 R288D mutation, underscoring the critical function of this residue for highly inducible transcription.
Within this spirit and in response to this challenge, a leading proponent of the whole-brain approach has revised both (1) the organismic definition of death to "the permanent cessation of the critical functions of the organism as a whole" and (2) the corresponding standard to permanent cessation of the critical functions of the whole brain (Bernat 1998, 17).
According to this revised whole-brain approach, the critical functions of the organism are (1) the vital functions of spontaneous breathing and autonomic circulation control, (2) integrating functions that maintain the organism's homeostasis, and (3) consciousness.
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