In addition to these selection criteria, deviations from the target unit-cell dimensions (specified as a fraction of each dimension) can also be used in the merging step so that only diffraction patterns with acceptable unit-cell dimension values are included in the merged reflection set.
Based on the standard deviation criteria for minimally clinically significant differences in HRQOL, an RS greater than 0.5 was interpreted as a moderate effect size, while a RS greater than 0.8 was interpreted as a large effect size [ 18].
The standard deviations of these criteria values are 0.52%, 0.18%, 1.00%, and 0.97%, respectively.
To analyze the differences in clinical parameters due to aging, and to minimize the potential confounding effects of diseases or abnormal measurements, we set inclusion criteria considering both the standard deviations of parameters that were collected and the normal range which was established by the American Medical Association.
Nine patients had inclusion or exclusion criteria deviations at study entry; none of these were considered major protocol deviations.
Individuals with excessive head motion were excluded from analysis (cut-off criteria: deviations exceeding 3 mm; sudden jumps greater than 2 mm).
For the standard deviation criterion, the function g11 solved by ATMDE1 is smaller than one by ATMDE, but they both can obtain the optimal result with an exceedingly small difference.
The quality of the QSPR models, i.e. the correlation between experimental p K a and the p K a calculated by each model, was evaluated using the squared Pearson correlation coefficient (R2), root mean square error (RMSE), and average absolute p K a error, while the statistical criteria were the standard deviation of the estimation (s) and Fisher's statistics of the regression (F).
Especially in the moderate stenosis group, for which the NMR signals are on average very low, many estimates fail to meet the quality criteria if the standard deviation for all three priors simultaneously was made twice as large.
where σ c is the standard deviation of the criterion placement (σ c = 0 if no criterion variability is assumed).
