Sentence examples for the course of directed from inspiring English sources

In these species, many of the traits have undergone intensive artificial selection over the course of directed genetic improvement.

Similarly, positioning of the substrate changed dramatically during the course of directed evolution studies of a designed Kemp eliminase.

However, collectively these studies suggest that increased active-site conformational flexibility, while detrimental to the chemical step, are likely key to the evolvability of these enzymes: the imprecision of the design process and of nonspecific hydrophobic interactions allows for the eventual tuning of catalytic residues during the course of directed evolution procedures.

Officer Byars did not issue any direction to the petitioner in the course of directing vehicular traffic, because Officer Byars was not then directing any such traffic.

The playwright concedes that in the course of directing his 1995 debut, Dealer's Choice, he and Daniels crossed swords.

This shared overall topology indicates that the most recent common ancestor of the strains examined contained each of the clusters and that the current sequences are the result of evolution over the course of direct transmission.

ALI and ARDS develop during the course of direct lung injury such as pneumonia, acid aspiration, ischemia/reperfusion after lung transplantation, or direct traumatic damage.

A total of 46 healthcare workers (6 physicians, 20 nurses, 20 ward assistants) participated in the survey; 32 (70%) reported having contact with at least one of the encephalitis patients through the course of direct patient care.

"From the beginning the concern was that the government would sweep up Americans' communications in the course of surveillance directed at people outside the country," Mr. Jaffer said.

One solution is to train artificial neural networks (ANNs) to stand in for the simulator during the course of searches directed by some optimization technique such as the genetic algorithm (GA) or simulated annealing (SA).

have directly tracked the motion of DNA across the surface of the histone octamer during the course of repositioning directed by the ISW2 complex (Deindl et al., 2013).