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The T-box transcription factor mab-9 has been shown to be required for the correct fate of the male-specific blast cells B and F, normal posterior hypodermal morphogenesis, and for the correct axon migration of motor neurons that project circumferential commissures to dorsal muscles.
At this point a key question arises: how are these binary switch circuits which readily explain the binary nature of the respective decision by progenitors, integrate into a single network that orchestrates the hierarchical development of pancreas progenitor to the various cell lineages by activating the correct fate decision in the appropriate cells (Fig. 1)?
Moreover, our experiments also indicate that this module relies solely on cells having acquired the correct fate that allows them to activate apical contractility and thereby their own internalization.
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However, in ceh-14 mutants, AFD and PVT still adopted the correct fates and simply failed to express certain differentiation markers, with electron microscopy being needed to reveal minor dendritic defects in AFD's fingers (Aurelio et al., 2003; Cassata et al., 2000).
Because accumulation of NMY-2 and apical contractions required the correct cell fate [ 10], this mechanism is very likely linked to cell fate maintenance, which provides robustness to the gastrulation process.
Evidences accumulated herein also demonstrate that the mesenchymal expression of Hoxa5 is essential for the correct cell fate of the secretory cell lineage in lung airway epithelium during development and regeneration.
Had the patient not been examined with FATE, the correct diagnosis and treatment would probably had been delayed for several hours since the patient had not yet developed the classical signs of a perforated ventricular ulcer.
It was as though such a cry in the dark could pierce the barrier if only the sender could sing the correct notes, if only the fates would line up just one time and make the world right again.
Intracellular transcriptional regulators and extracellular signaling pathways together regulate the allocation of cell fates during development, but how their molecular activities are integrated to establish the correct proportions of cells with particular fates is not known.
In epithelial stem cells, polarity proteins control asymmetric cell division by regulating the polarised localisation of cell fate determinants and the correct orientation of mitotic spindles.
Transcription factors determine cell fate decisions by controlling the correct temporal sequence of lineage-specific gene activation or repression.
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