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They are the basis of ongoing work developing templates for all conditions in the core panels, as well as those in the secondary target category.
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In adherence to the RAND method, the core panel critically evaluated the indicators with high agreement in step four.
However, TYR-I is included in the core panel for historical reasons and because of the effectiveness of treatment.
The main category, referred to as the core panel, includes those conditions considered appropriate for newborn screening.
Twenty-three of the 29 conditions in the core panel are identified with multiplex technologies such as MS/MS.
For each of the markers in the core panel, the nucleotide length of the most common allele was determined by sequence analyses in different cat breeds (Table 5).
Inherent to conditions in the core panel is the need to maximize detection in screening while minimizing excessive false positives being referred into the health care system.
The differences in expectations between the conditions in the core panel and those in the secondary target category should be noted.
For conditions in the core panel that are positive on screening due to specific analytes being elevated, the secondary targets are identified in the diagnostic laboratory.
For nine markers, 96 98% of the data were called consistently and six of these nine loci were selected for the core panel.
Most conditions placed in the secondary target category are part of the differential diagnosis of a condition in the core panel.
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