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Digital leaders no longer manage; rather, they enable workers to innovate and facilitate the core feedback loop of user responses to firm decisions and execution.
But of course, in games, the hero never makes it, the girl can never help him escape violence, because in games, violence is often the core feedback loop, the defining mechanism.
In the core feedback loop of the Drosophila clock, transcription factors CLOCK (CLK) and CYCLE (CYC) heterodimerize and activate transcription of period (per) and timeless (tim) through binding to their upstream and intronic E-boxes.
The PER and CRY proteins also heterodimerize and inhibit CLOCK/BMAL1 activity leading to reduction in PER and CRY expression, thereby completing the core feedback loop responsible for the circadian rhythm.
Exciting studies also suggest that Timeless could play a role in conveying phase-resetting zeitgebers arising from DNA damage to the core feedback loop.
FREQUENCY (FRQ) together with the FRQ-interacting RNA helicase (FRH) then function as the negative elements in the core feedback loop of the Neurospora clock.
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After aligning translated W. smithii contigs and singletons from this transcriptome with other insects, we determined that there was no significant difference in the average divergence of W. smithii from the six other taxa between the core feedback-loop genes and post-translational modifiers.
Pdp1 acts together with vrille in a modulatory feedback loop on the core transcription/translational feedback loop in insects (Blau and Young, 1999; Cyran et al., 2003; Glossop et al., 2003).
The core negative feedback loop is interlocked with positive feedback loops to maintain robust rhythmicity.
These positive feedback loops are interlocked with the core negative feedback loop, a feature that is shared in animal clocks.
Cryptochrome, which functions as part of the core clock feedback loop in mammals, serves as a photopigment in the fruit fly [15].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com