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The amount of PKC θ was decreased in the particulate fraction of the cDKO heart compared with the control heart.
Consideration of these facts requires comparison of twitch duration between the diabetic heart and the Control heart at the same rate of stimulation.
For comparison purposes, each blot included the same control and the data obtained from all experimental groups were expressed as a ratio of the control heart.
We did not measure twitch duration of the heart and are unaware of any study that has paced the diabetic heart at the same rate as the Control heart in order to quantify the diabetes-induced prolongation of twitch duration.
For the first case, compared with the control heart, the diabetic heart has a lower value of peak efficiency, but the same optimal afterload and the same peak afterload.
But, if measurements had been made at or around the optimal afterload (the third case), then one would find that the diabetic heart has the same efficiency as the control heart.
Similar(53)
Macroscopically, the control hearts appeared to be more edematous.
Lipid depositions were not found in the control hearts (Fig. 5D, F).
Microscopically, the anterior apical regions of the control hearts showed extensive interstitial haemorrhage and oedema (Figure 6D and 6E).
All data were normalized to miR-145 and compared with expression levels observed in the Control hearts (Table S3).
The extent of haemorrhage and oedema in the anterior apical region of the lidocaine-treated hearts was more similar to that of the control hearts (Figure 6G).
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