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However, these approaches that rely on high-throughput screening methodologies primarily utilizing the yeast deletion collection or plasmid-based genomic libraries are limited in terms of the constrained range of genetic perturbations explored and the ability to rigorously validate the findings.
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Perhaps this was due to the less constrained range of motility that is associated with the matrix-free CWA technique, compared to a more constrictive microenvironment presented to cells in the CIA method.
This may also result in a more constrained range of variation, since the sphenoid housed these essential neurological structures.
While its constrained range makes it easier to monitor the lynx population, it also makes it harder to safeguard the feline if something like a new virus suddenly infected rabbits in this southwestern corner of Europe.
Worse still, if the apparent optimization is in fact no different to randomization amongst a constrained range, it is inescapable that half of all such procedures worsen cardiac efficiency rather than improve it.
Besides, at certain constrained range of operation conditions, complex dynamics can be observed, including the onset of chaotic behavior.
Lange's Metalmark butterfly, Apodemia mormo langei [ 43], is an endangered subspecies characterized by a constrained range and a unique phenotype.
Although Mcm2/Ki67 and geminin/Ki67 ratios were normally distributed, because of their intrinsic constrained range of results these were treated as non-parametric.
Future research could evaluate cCBT within a more constrained range of severity of depression; though we noted that use was low for people with all severities of depression.
... The model behavior is robust across the constrained parameter ranges, but with sufficient flexibility to describe a wide range of observed phenomena.
Importantly, we did not test whether the rare species distributions were confined to a limited climate space, although it is almost certain that most would show small climate envelopes reflecting their constrained ranges.
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