Sentence examples for the consequences of targeting from inspiring English sources

P McLaughlin (Groningen, the Netherlands) investigated the consequences of targeting monoclonal antibodies to normal and tumour tissue in a transgenic murine model expressing human EpCAM.

In this study, we used genetically engineered mouse and human xenograft models to evaluate the consequences of targeting eNOS in PDACs.

However, the consequences of targeting α6β4 integrin with an antibody on normal tissue homeostasis and repair processes haven't been yet studied.

Moreover, we analyzed the consequences of targeting a copper binding non-mitochondrial protein (PaMT1) to the mitochondrial matrix on the type of respiration and on lifespan.

Bioengineered Human Skin Equivalent (HSE), which have been shown to mimic their normal and wounded counterparts, have been used here to investigate the consequences of targeting β4 to establish toxic effects on normal tissue homeostasis and epithelial wound repair.

We used three-dimensional tissues as a platform to test the consequences of targeting β4 with these antibodies, which are specific to human β4, first in a static three-dimensional tissue model of non-wounded human epithelium and second in a dynamic three-dimensional tissue model of wound healing.

To investigate the possibility of function blocking antibodies to NRP1 as potential therapeutics, and study the consequence of targeting NRP1 in murine tumor models, panels of antibodies that cross-react with human and murine NRP1 were generated from a designed antibody phage library.

The consequence of targeting tumour cells with ALM is effective inhibition of tumour cell growth in vitro.

If bombs are in play for your level, weigh the consequence of targeting them versus getting your points up.

Here, we attempt to quantify the consequences of target site structure on predicted hybridization using sequences sampled from the human genome.

Initial clinical development should focus on proof-of-principle, a demonstration that the drug produces inhibition of the biological target at doses that are well tolerated, and that the consequences of target inhibition can be identified and measured using validated surrogates for clinical benefit.