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Director of the Triangle Center on Terrorism and Homeland Security, David Schanzer, comments on the consequences of targeted, fear-based rhetoric.
Thus, the consequences of targeted knockdown are not reflective of proteins that merely directly interact, but point to a defined and inter-dependent complex organization.
As an approach to defining huntingtin's essential functional molecular interactions in a mammalian system, we, and others, are studying the consequences of targeted inactivation of the murine HD gene.
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P McLaughlin (Groningen, the Netherlands) investigated the consequences of targeting monoclonal antibodies to normal and tumour tissue in a transgenic murine model expressing human EpCAM.
In this study, we used genetically engineered mouse and human xenograft models to evaluate the consequences of targeting eNOS in PDACs.
Moreover, we analyzed the consequences of targeting a copper binding non-mitochondrial protein (PaMT1) to the mitochondrial matrix on the type of respiration and on lifespan.
However, the consequences of targeting α6β4 integrin with an antibody on normal tissue homeostasis and repair processes haven't been yet studied.
Bioengineered Human Skin Equivalent (HSE), which have been shown to mimic their normal and wounded counterparts, have been used here to investigate the consequences of targeting β4 to establish toxic effects on normal tissue homeostasis and epithelial wound repair.
We used three-dimensional tissues as a platform to test the consequences of targeting β4 with these antibodies, which are specific to human β4, first in a static three-dimensional tissue model of non-wounded human epithelium and second in a dynamic three-dimensional tissue model of wound healing.
What are the consequences of targeting survivors rather than a healthy, unaffected population?
Along these lines, there would appear to be particular value in investigating the consequences of targeting of the same protease to different subcellular compartments in vivo, as was done, for example, in cultured neurons with NEP [ 47].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com