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10 However, there have been only a limited number of studies investigating the consequences of alterations in microvascular prostanoid synthesis.
The consequences of alterations to the immune system are potentially serious because even subtle changes can diminish resistance to infections and reduce responses to vaccines.
This enables the exploration of the consequences of alterations, e.g., the dose of the ligand or the compliance of the patient, on the disease progression.
We then investigated the consequences of alterations in PLD activity on mTOR signaling pathway, and found that both mTORC1 and mTORC2 are modulated by PLD and may participate in the trophic responses we observed in L6 myotubes.
It is anticipated that on-going studies will provide data that more rigorously test this hypothesis and provide insights into gestational age-dependent programming effects and the consequences of alterations in intrauterine life on risk profiles for adult diseases.
These traits can be the consequences of alterations that are directly changing the protein function, or they can emerge after several gene expression regulation steps, caused for example by alternative splicing or methylation.
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Here, we used Stip1 heterozygous mice (STI1−/+ mice), as well as mice overexpresssing four- to fivefold more STIP1 (STI1TGA mice), to investigate the consequences of alteration of STIP1 levels in vivo.
The consequence of alterations in the P53 target genes observed in this study are altered growth/proliferation and a potential failure to elicit appropriate responses to apoptotic-inducing stimuli, such as chemotherapy.
Enhanced insulin release in p38δ Δ/Δ mice was not the consequence of alterations in the β cell mass, in the pancreatic islet architecture, or in insulin content.
He also posits that celiac and inflammatory bowel diseases may be the consequence of alterations in bowel flora resulting from multiple courses of antimicrobial drugs.
To determine if the loss of diaphragm force generation in response to hyperglycemia was the consequence of alterations at the level of the contractile proteins, we assessed the force-pCa relationship in 360 single permeabilized diaphragm fibers.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com