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In conformational selection, addition of binding partners can result in a population shift in the conformational ensemble of a disordered protein (see section 4.2) toward the conformation that is most favorable for binding.
In general, breeders look to produce horses with good gaits and an aptitude for driving, while keeping the conformation that makes the Norman Cob one of nine French draft breeds.
This led us to hypothesize that PTB interaction with the IRF2 IRES might trigger a change in the conformation that helps in the recruitment of other hitherto unknown trans acting factors and ribosomes, thus facilitating translation initiation.
For this reason, we use the conformation that produces the highest druggability score when there are multiple crystallized conformations available.
This suggested that for the WT enzyme, the ligand stabilized the conformation that was observed in the crystal structure.
In the product state, in which ADP has left the active site, the Gly-rich loop assumes the conformation that is intermediate between the open and closed states.
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The conformations that are identified, however, are still useful; the results of the simulation are therefore incomplete, but not necessarily wrong.
The conformations that describe the fluctuations of residues from the average in the principal directions of motion are generated using the elastic network formed by connecting all neighboring heavy atoms.
The conformations that proteins adopt in solution are a function of both their primary structure and surrounding aqueous environment.
Until recently, however, comprehensive experimental measurement of the conformations that a free ligand adopts in solution conditions (its dynamic 3D structure) has not been possible.
But cooling to low temperatures changes the conformations that the protein adopts, and usually causes fewer conformations to be present.
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