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In order to ensure that subjects maintained high attention, the conditioning sequence was divided in 2 blocks of ∼10 min each.
In total, 50 stimuli were presented during the conditioning sequence; 25 for the high pain face and 25 for the low pain face.
An initial validation of brain activations in response to pain during the conditioning sequence revealed a comprehensive representation of pain processing regions [high pain > low pain], including the ACC, thalamus, and bilateral insula; see Table 1.
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The experiments used both regular pacing and PES procedures, which imposed an S2 extra stimulus following eight-beat (S1) conditioning sequences at S1S2 intervals progressively shortened with each stimulus cycle.
Therefore, their output random sequences can be used without the conditioning component in Section 3.1.
This sequence of delivering the test stimuli, followed by the conditioning stimulus, and ending with re-delivering the test stimuli constituted the first CPM trial (CPM1).
For convenience, we drop the conditioning on.
Generating Gaussian values at the conditioning points.
The conditioning is relentless and severe.
The conditioning effect lasted for one day after conditioning trials.
The conditioning protocol was divided into three periods: preconditioning (1 day), conditioning (8 days), post conditioning (1 day).
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