With regard to the first question, the nature of LIE usage by EPs was found to most often involve the concomitant use of two or more systems.
With many complementary properties such as excellent detergency, emulsifying, foaming and dispersing traits to the proteases a concomitant usage of biosurfactant and protease could offer improved efficacy as detergent additives.
If a patient received a fixed combination drug containing LABA and ICS, the respective quarter of the year was considered as a quarter with concomitant usage of LABA and ICS (irrespective of any other drugs).
Selection and dosage of immunosuppressants, dosage of GC, and concomitant usage of plasmapheresis were determined at the discretion of the attending physicians.
In our study, earlier observations that concomitant usage of nephrotoxic drugs increases the risk of renal injury development were confirmed [ 4, 27].
Selecting interacting drugs for TP-DI investigation is mainly based on potential concomitant usage, PK and PD properties and the therapeutic window of selected drugs.
Concomitant usage of apixaban and enoxaparin resulted in a 42% increase in peak anti-Xa activity.
Concomitant usage of medications other than CBZ was determined by clinical condition of the patient and was not limited due to the naturalistic nature of this study.
Concomitant usage of LABA and ICS could also be assured by prescribing both compounds separately, but in a close temporal relationship (usually at the same day in clinical routine).
Taking into account a quarterly documentation of prescribed drugs, a separate prescription of both a LABA and an ICS compound was considered as concomitant usage of LABA and ICS if given in one quarter (irrespective of any other drugs).
