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These results were used to develop the Complete cAMP Model.
The Complete cAMP Model illustrates several important features of the pathway.
Therefore in all further developments of the complete cAMP pathway models Krh was retained as a direct inhibitor of PKA.
We have created deterministic mathematical models of the PKA module of the pathway, as well as the complete cAMP pathway.
The parameters of the Complete cAMP Model are given in Table 4, including both estimated and experimentally derived parameters.
As a step towards developing a deterministic model of the complete cAMP pathway, we first constructed a conceptual model named Simplified cAMP Model A (Table 1).
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Our Complete cAMP Model represents the first effort to consolidate all the known elements of the cAMP pathway into one deterministic mathematical model.
The cAMP profile computed by simulation of our Complete cAMP Model after parameter estimation is in good agreement with previous observations.
Our Complete cAMP Model will no doubt be improved and tested further in the future.
This Complete cAMP Model (Table 1 and Figure 7) consists of several distinct "modules" which are described below.
With the gassings complete, the camp was renamed Zemun concentration camp and served to hold one last group of Jews who were arrested upon the surrender of Italy in September 1943.
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