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Overall, the complementary side does not seem to play a significant role in the interaction between the peptide and the Ac-AChBP (Fig. 2B).
Additionally, a comparison of the α3β2 and α3β4 nAChR models allowed us to determine the key residues on the complementary side responsible for increased binding of LvIA to the α3β2 vs. the α3β4 subtype (Fig. 5).
Hydrophobic contacts are also formed with C186 and C187 of Loop C and L106 and L116 of the complementary side.
Binding to the complementary side of the helix by LNA 2 did not result in this conformational switch.
Instead, hydrophobic interactions with the complementary side (equivalent of the β-subunit) dominate the binding interaction at α7.
Because this aliphatic adjunct interacts mostly with the complementary side, we began by focusing on the known differences between α4 and β2 subunits in this region.
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"The best results have come from a tailored mix of therapies - and theatre and the arts are a part of this complementary side of a broad spectrum of therapies.
The complementary binding side is situated at the interface between the LvIA and the β-sheet of another Ac-AChBP protomer.
On the complementary binding side, Ser-4 and Asn-9 of LvIA form hydrogen bonds with Ser-165 and Gln-55 of Ac-AChBP, respectively.
(B) On the complementary binding side, Ser-4 and Asn-9 of LvIA forms a hydrogen bond (represented by yellow dashed line) with Ser-165 and Gln-55 of Ac-AChBP, respectively.
In a recasting of the traditional cheese course, Mr. Zakarian asked his pastry chef, Nancy Kershner, to invent a complementary side dish for each of a half-dozen cheeses.
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