Sentence examples for the complementarity to from inspiring English sources

In the case of antibodies, somatic hypermutation then acts to improve the complementarity to a given antigen and increase antibody affinity.

To test this, the bases adjacent to motif 1 were substituted such that the complementarity to 18S rRNA was increased to the 5', to the 3' or in both directions (Figure 3A).

According to the prevailing model, posttranscriptional repression by miRNA is determined by the complementarity to the miRNA of the target mRNA[ 27].

Second, the target sites predicted in this study were detected only based on the perfect complementarity to the seed sequences as mentioned above, and it is necessary to confirm the functionality of these target sites experimentally.

Flexibility around the ligand-binding site improves its accessibility, facilitates the ligand entry and allows subsequent optimisation of the surface complementarity to maximise the number of contacts between ligand and protein upon binding.

Edited miRNAs can change the miRNA complementarity to target sequences and increase the diversity of miRNAs in the cell [ 24, 46].

ΔG°break-target: The free energy cost for opening bps in the region of complementarity to the target so that the binding site becomes completely open.

The alternative splice site is located 13 nt upstream from the predicted complementarity to SNORD115 RNA and leads to a truncated serotonin receptor (Cavaille et al. 2000).

Depending on the degree of complementarity to the target mRNA, the mechanism of silencing target mRNA expression will be one of the following: 1) if there is perfect complementarity to a target mRNA, there will be target mRNA cleavage; and 2) in the case of incomplete complementarity, translational repression or alteration of mRNA stability will occur [ 20].

We found that for suppression of VEGF-A, the length of complementarity to the seed region, as well as the total complementarity of the guide strand to the target were important determinants of activity.

Each CRISPR spacer, however, is in principle constrained to target a specific phage because of the requirement for complementarity to the entire RNA sequence (though see below on the possibility of CRISPR seed sequence).