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To circumvent this possibility, the competence system should be deleted once an optimal attenuated vaccine strain has been generated.
Okinaga T, Xie Z, Niu G, Qi F, Merritt J Examinationn of the hdrRM regulon yields insight into the competence system of Streptococcus mutans.
The competence system is clearly part of the regulation of genetic transformation, with the likely function of providing for gene exchange and eventual evolution.
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Further, by identifying candidate transporters through a biochemical approach, we expect to be able to delete components of the natural competence system, therefore confirming their role in this process.
It is also possible that the Rickettsia T4SS is an amalgam of an effector translocation system and a DNA competence system, especially considering the redundancy of several of its components.
While S. pneumoniae does not possess an USS, it does contain a stress-induced competence system associated with the fratricidal secretion of antibiotics that has been suggested to contribute to the S. pneumoniae distributed genome [ 49].
Here the phase zero of our action oriented competence system is at stake.
The competence delivery system is especially important for identifying equipment condition, equipment isolation for maintenance, pre-start-up status and process deviations.
The complexity of natural competence systems and diversity of streptococcal competence genes has made in-silico prediction of natural competence difficult [ 95].
Transformation, by contrast, is a bacterium-programmed mechanism of HGT that is mediated by natural competence systems encoded in the genomes of many bacteria (Lorenz and Wackernagel 1994; Claverys et al. 2009).
Competence systems in Gram-positive bacteria share many structural features with the closely related T4P systems and T2S systems 4, 10, 11 (Table 1).
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