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In recent years, key mechanistic and biophysical insights have been obtained by employing the CompEL protocol to address a wide range of questions on ion channels and permeation.
Nonetheless, it is worth noting that that exploratory analyses of the COMPEL data demonstrated that concomitant mild or moderate anxiety or depression did not have a significant negative impact on outcomes.
The COMPEL Study provides additional clinical evidence for the consistency of the efficacy and for the long-term safety and tolerability of onabotulinumtoxinA for the prevention of headache in those with CM who have been treated with onabotulinumtoxinA every 12 weeks over 2 years (9 treatments) with the fixed-site, fixed-dose injection paradigm.
In the COMPEL database, several hundred composite elements are described with evidences that their regulatory functions differ from those provided by their individual components [ 40].
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