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Model independent similarity and dissimilarity factor methods were used for the comparison of dissolution results.
The comparison of dissolution profiles (dissolution amounts Q n ) of individual samples is shown in Table 1 and illustrated in Figure 1.
Furthermore, the comparison of dissolution profiles for formulations U1, U4, and U7 containing 100, 200, and 300 mg of Neusilin US2 reveals that MDT decreases but the dissolution rate based on diffusion (K) and DE increases with increasing the silicate content (Fig. 4).
This report focuses on the analysis of dissolution data to evaluate the application of the DDSolver program to two dissolution studies: (1) the comparison of dissolution profiles between different products, (2) fitting of drug release data to the K-P model and its modifications.
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Building the bootstrap based f2 module into DDSolver makes the similarity comparison of dissolution profiles convenient and accurate.
Compared to f2, bootstrap-based f2 is more accurate in similarity comparison of dissolution profiles and especially important if the f2 value is less than 60 [ 30].
The comparison of positive control with negative control clearly demonstrated that clot dissolution does not occur when water was added to the clot.
In our thrombolytic assay, the comparison of positive control with negative control clearly demonstrated that clot dissolution does not occur when water was added to the clot.
Because DDSolver can aid in reducing calculation errors and calculation time, it is a suitable tool for day-to-day comparisons of dissolution data.
Dissolution analysis involves a comparison of the dissolution profiles and the application of mathematical models to describe the drug release pattern.
For comparison, the degree of dissolution of the SiO2 nanoparticles was lower, and it was unaffected by the presence or absence of serum, whereas the TiO2 and CeO2 nanoparticles displayed very little, if any, dissolution.
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