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We leveraged our empirically-calibrated models [ 15, 33, 34] to validate the companion model by comparing projected model outcomes for selected countries to those obtained using the companion model.
We leveraged this work to develop a series of rotavirus disease models to explore uncertainties associated with analytic choices about model structure [ 17], and conducted corroboration exercises by comparing projected model outcomes to those obtained using the companion model described below.
The companion model was structured as a static cohort simulation model [ 6, 18, 19, 37], and employed simplifying assumptions relying on insights from the more complex model (e.g., the plausible ranges of parameters and the effects of simplified natural history on model outcomes) [ 6, 18, 19].
This suggests that, for both vaccines, the magnitudes of the actual financial requirements and reduction in disease burden might be different from the values projected using the companion model if actual population dynamics are different from those projected by the version of population prospects that we used.
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In doing so, we adjusted the key parameter assumptions of the companion models to closely match those from the more complex models.
The corroboration exercises showed that, for both rotavirus and HPV, our results using the companion models are consistent with those obtained from more comprehensive static models (Additional file 1 Table S1).
Using the validated companion model, we synthesized population-level data on demographic structure, country-specific disease burden (incidence of cervical cancer), medical utilization patterns, and costs (expressed in 2005 international dollars [I$]) in order to estimate the health and economic consequences associated with HPV vaccination in the GAVI countries [ 6].
The N.H.T.S.A.'s conclusion was that, in the first seven years that the Pinto and its later companion model the Bobcat were on the road, two dozen of their occupants were killed by fires from rear collisions.
The upper panel in Figure 1 shows the simplified schematic of natural history represented in the Excel-based companion model.
The Excel-based companion model is applied to birth cohorts (born in 2010) in the 72 GAVI-eligible countries.
My final gripe is with the Chevy Colorado, a new small pickup that recently went into production alongside a companion model, the GMC Canyon.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com