Most of these commonly active genes exhibited comparable fold changes suggesting that they do not significantly influence the magnitude of the uterotrophic response.
Pairwise activity similarity, s refers specifically to the number of commonly active targets of two drugs.
We extracted the timecourse from the IFO ROI that was found to be commonly active during the observation and experience [17] for all three experimental conditions using marsbar (http://marsbar.scourceforge.net; M.Brett, J.-L. Anton, R. Valabregue, and J.-B. Poline, ROI SPM toolbox, Abstract).
Cathepsins of the cysteine protease family and in particular cathepsin-B are commonly active in the tumor microenvironment, contributing to the regulation of angiogenesis and invasion during cancer progression [10], [11].
Proteases commonly active in the tumor microenvironment can cleave the linker and disengage the masking peptide, thereby enabling CAR-T cells to recognize target antigens only at the tumor site.
The combination of these two data sets improves the common genomic comparison between apple and tomato, expanding the number of possible genes commonly active in both (and presumably other) species from early development through post-harvest ripening.
We further predicted that motor-related regions would be commonly active for the perception and production of linguistic prosody.
Interestingly, the androgen receptor (AR) is commonly active in CRPC despite castrate levels of circulating testosterone [1], [2] and intense nuclear AR immunostaining in CRPC bone metastases is related to a particularly short survival [3].
The comparison of tumour to normal lung tissue is therefore likely to be an effective way to identify potentially targetable gene products that are not commonly active in the bulk of normal cell types.
