The knee was the most common symptomatic joint, followed by the metatarsal, the ankle joint and the wrist.
The C5/6 facet joint was the most common symptomatic joint either alone or in combination with another joint (Table 1).
Raised inflammatory markers not associated with clinical symptoms are the most frequent adverse effects, whereas fatigue, myalgia and nausea are the most common symptomatic adverse events.
Double aortic arch is the most common symptomatic vascular ring, accounting for 50 60 % of vascular rings [22].
The most common symptomatic manifestation of mild to moderate atherosclerotic PAD is intermittent claudication [ 4], observed in ~5% of individuals older than 60 years [ 5, 6].
Intermittent claudication (IC) is the most common symptomatic manifestation of PAD, and typically occurs in up to one third of patients with this disease [ 1].
CVID is the most common symptomatic primary immunodeficiency in adults, estimated to affect ∼1 in 25,000 individuals, and has a higher prevalence in people of northern European descent (Table 1).
Primary end points were defined as the first recorded diagnosis of the 12 most common symptomatic manifestations of CVD, irrespective of underlying disease mechanism, arising from pathology in the head, heart, abdomen, or legs.
This may be viewed as a weakness of the study design and, certainly, a consequence of the limited scope of our study since we decided to focus on the description of the distribution of patients' common symptomatic profiles.
Most importantly, clinicians should refrain from non-rationalized or common symptomatic treatments that could accelerate the progression of ALI.
