During manual curation sprints of the CCDS data set, we noticed that some types of manual annotation updates were conflicting between the collaborating groups at a higher frequency, resulting in time-consuming discussions in order to reach agreement.
While each of the collaborating groups independently performs QA tests in their annotation pipelines, an additional layer of QA tests are applied to the set of identified matching genome annotations prior to accepting them and assigning a CCDS ID (Table 2).
Having defined a model in which the choice between senescence or quiescence can depend upon mTOR signaling, the collaborating groups addressed an earlier observation that some p53 inducers, such as the DNA damaging agent doxorubicin, promote senescence while others, such as Nutlin 3a, lead to quiescence in the same cell type.
Results of these trials have been analyzed together with data from the UKPDS by a collaborating group of the trial investigators (9).
Although some of these issues were project-specific (being influenced by the needs of the learners, the aims of the project and the partners involved), the evolutionary process described in this case study illustrates that there can be a steep learning curve for the different collaborating groups within the project team.
We wish to acknowledge the contribution of the Jhpiego Concept Analysis Collaborating Group who provided guidance and review of this work: Linda Bartlett, PhD; Catherine Carr, DrPH; Amnesty Lefevre, PhD; Luc de Bernis, MD; Carey McCarthy, MPH; Lois Schaefer, MPH; Jeffrey Smith, MD; Udaya Thomas, MSN, MPH; Tegbar Yigzaw, MD; and Barbara Rawlins, MPH.
The authors wish to thank all of the GEMO collaborating groups for their contribution to this study.
We wish to thank all the GEMO collaborating groups for their contribution to this study.
It is important to note that these standards address specific problem areas, are not a comprehensive set of annotation guidelines, and do not restrict the annotation policies of any collaborating group.
