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Women were not warned in advance about these tests, although they were aware that they needed to pass the CO test to claim the voucher.
Participants who self-report as quitters at the six-month follow-up interview will be invited to perform the CO test in the clinic.
Analysis of the RR-interval in the two minutes prior to and immediately following the CO test segment indicated that there was no difference in mean RR-interval or the standard deviation of RR-interval (see sample data, Figures 1 & 2) which would suggest that the CO-rebreathe test did not affect the heart rate data.
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The CO tests were used to determine which team will win the prize.
Thus, for patients with ASC undetected by the co-test, a regular follow-up Pap test would be highly recommended.
As mentioned, the sensitivity, specificity, and accuracy of the co-test are 89.19%, 70.24%, and 76.03%, respectively.
The colposcopy referral rate of the co-test is 47.9%, which is 25.2% less than that of HPV-HR alone.
In the most recent guidelines from the United States, HPV16/18 testing is one of the options to triage women found to be HPV-positive but cytology-negative in primary screening using the co-test approach 202.
The question is what proportion of the HPV-positive, cytology-normal women have transient HPV infection, and how many of them will turn out to be HPV-negative when the co-test is repeated in 1 year.
According to the recent guidelines from the United States, women with HPV-positive and cytology-negative screening results can be either followed with the co-test 12 months later or triaged with the HPV16/18-specific HPV16/18-specific testolposcopy 201.
Depending upon the validity, we will decide to either use cotinine test (or CO test) in the actual trial or just the subjective assessment as a proxy.
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