Initially, Hogenesch told me, it was assumed that this clockwork was limited to the brain.
The accumulation of Per2 and Bmal1 transcripts, as strongly cycling representatives of the circadian clockwork, was thus assessed in the liver and pituitary gland of sham-operated and adrenalectomized mice sacrificed every 6 hours after 10 days of DRF or NRF (Figure 4).
When others took it to suggest that, once the universal clockwork was wound up there would be no further need for divine intervention to keep the planets in their orbits, he was dismayed.
In fact, some of the first clockwork was designed to spin meat on a spit, a process that takes us from sausages to Swiss watches in about two hundred years.
The catch is, clockwork wasn't invented for another 1,000 years and the mechanism – corroded, squashed, fragmented and incomplete – has puzzled scholars for a century.
Perhaps it was hard to pronounce, perhaps he just thought it was a bit of fun, but the truth is that the guffaw of laughter from the other kids, regular as clockwork, was a daily ordeal.
Interestingly enough, Su Song's treatise on astronomical clockwork was not the only one made in China during his day, as the Song Shi (compiled in 1345) records the written treatise of the Shuiyunhun Tianjiyao (Wade Giles: Shui Yun Hun Thien Chi Yao; lit. Essentials of the [Technique of] making Astronomical Apparatus revolve by Water-Power), written by Juan Taifa.
The British empire, navigated by jeweled clockwork, was set on course by collaboration and a touch of well-timed fraud.
"Hezbollah, like clockwork, was instigating something small every month or two," the U.S. government consultant with ties to Israel said.
"Clockwork was more of an experimental song.
