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The classification was evaluated using standard metrics.
Statistical significance of the classification was evaluated by comparing the overall accuracy of the 12-gene signature with that of 1000 random signatures of the same size using the same algorithm.
Similar(58)
Nevertheless, the validity of this classification was evaluated only in few studies so far and further research is clearly needed [ 20– 23].
The classifications were evaluated by their ability to distinguish between patients differing in survival.
The experimental tests were performed at different wheel speed and air flow rates then the performance of the air classification was evaluated by plotting the Tromp curves.
The relationship between the variables and the clinical classification was evaluated using Mann-Whitney or Kruskal-Wallis tests for continuous variables.
The skeletal classification was evaluated using the ANB angle [12].
Disease location according to the Paris classification was evaluated only in patients with CD and UC with a complete diagnostic workup [ 34].
Given that the control group included healthy subjects with no lesions and subjects with benign lesions, the specificity of classification was evaluated separately for these two groups.
Furthermore, the significance of sample composition (cancer and normal tissue) on subtype classification was evaluated and the persistency of the subtype classification in samples with different Gleason score from the same patients was assessed.
The incremental benefit of adding markers of systemic inflammation to the MSKCC factors to improve prognostic classification was evaluated by calculating the net reclassification index (NRI) (Pencina et al, 2008).
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