The classical action of androgen receptor (AR) is to regulate gene transcriptional processes via AR nuclear translocation, response element binding and recruitment of, or crosstalk with, transcription factors.
According to the formulation, the most probable dynamical trajectory connecting the initial and final atomic configurations, is determined through minimizing an appropriate object function that is derived from the classical action by imposing dynamical conditions as required as the conservations of total energy.
Rather than concentrating on the integration of the equations of motion, we examine various transition pathways by minimizing the classical action of (1) above with as much low potential energy as possible.
The path { q j } is a collection of sequential structural frames with the fixed initial q0 and final q P. Then the classical action can be written as (1) S = ∑ j = 0 P − 1 L j ({ q j } ) Δ, where the discretized Lagrangian of the jth temporal frame is defined as (2) L j = ∑ I = 1 N m I 2 Δ 2 (q I, j − q I, j + 1 ) 2 − V ({ q j } ).
Perry, who has also played football for the Socceroos, has the smooth classical action of an old-time fast bowler and she delivered four superbly disciplined overs.
Some recent studies suggest these neuropeptides can act directly on the gonad, in addition to their classical actions through the HPG axis.
AT1 receptors mediate most of the classical peripheral actions of AngII.
The classical genomic action mechanism of ER action typically occurs within hours, leading to activation or repression of target genes.
These authors suggested that hypertensive stimuli such as Ang II, catecholamines, and aldosterone initially induce a moderate increase in blood pressure via their "classical" actions in promoting Na+/water retention, vasoconstriction, and/or increased sympathetic drive [ 68, 69].
