He put the class terms "them" and "us" into political currency.
One of the classes, termed c2, appears to involve a strand passage event between distant segments of genomic DNA.
Regions altered in both classes with similar frequency are plotted close to the y = x diagonal, whilst off-diagonal points represented regions primarily altered in one or the other of the classes (termed differential imbalance).
The first class, termed the p21 family, includes p21 WAF1, p27 KIP1 and p57 KIP2, which inhibit the activity of G1- and S phase and to a lesser extent the mitotic cyclin/CDK complexes.
Down-regulated genes (Fig. 2) mostly belong to the functional class termed "Energy Metabolism"; 42 of the 118 repressed genes (35%) belong to this group, and they are amongst the most highly repressed.
The plethora of terms reflects the difficulty of choosing a "best" canonical class term for the precancerous lesions.
It is unclear how the latter class, termed target battery [ 8], which might be subtly regulated on the protein level [ 6, 7], contributes to proper phenotypes.
The second category of "bacA" genes was poorly expressed in WT nodules and, similarly to the (2.3) class (termed "fixJ", 124 gene probes), maximally expressed in bacA as well as fixJ nodules.
The fifth class, termed HTH-Dx-SOR, includes Dx-SORs (2Fe-SOR) with an extended N-terminal helix turn helix (HTH) domain present in transcription regulators.
The sixth class, termed TAT-SOR, includes SORs from only a few organisms, such as Desulfuromonas acetoxidans DSM 684 and Geobacter sulfurreducens, and the sequences are preceded by a putative twin-arginine signal peptide that suggests their periplasmic localization.
