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Our aim was to investigate whether neurokinin B (NKB) is the circulating factor associated with PE.
Conclusion: We conclude from these observations that NKB is not the circulating factor associated with increased vascular resistance in PE. (Am J Obstet Gynecol 2003 188 196 202).
Later, the same team showed that the circulating factor responsible for this was tumor necrosis factor α (TNF-α) [9, 10], even though later studies have implicated other cytokines, such as interleukin-1β [11].
The question is what is (are) the circulating factor(s)?
Nonclinical models and data from clinical trials indicate that relaxin is the circulating factor responsible for these changes.
These studies suggested that the circulating factor might include DNA in ICs and fit well with data showing that CpG DNA oligonucleotides can enter cells and stimulate TLR9.
Similar(52)
The circulating factors presented by a shared circulatory system could be the possible explanation for the observed rejuvenation.
First, we cannot exclude that multiplex measurements did not correlate with single assays for some of the circulating factors.
The PI3K/Akt and MAPK pathways are both downstream targets common to many of the circulating factors typically upregulated with obesity [ 24- 28].
The identity of the circulating factors, such as cytokines and metabolites, and mechanisms mediating the systemic response of cardiac specific mIGF-1/SIRT1 remain to be addressed (Fig. 7).
The circulating factors involved in remote organ damage are not totally known, but reactive oxygen species, cytokines, and complements factors associated with increased circulating leukocytes are likely to play a key role.
More suggestions(15)
the integrating factor
the propagating factor
the circulating blood
the circulating level
the driving factor
the circulating water
the circulating immunoconjugate
the circulating tumor
the circulating air
the circulating estrogen
the circulating flow
the deciding factor
the circulating acceptance
the circulating velocity
the circulating system
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Justyna Jupowicz-Kozak
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