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In an attempt to expand the scope of clinical data, and to focus the scientific yield on comparative effectiveness, CORRONA launched the CERTAIN study in late 2010.
14 34 35 The alternative target of LDA was attained in almost two-thirds of CZP patients at 6 months in the CERTAIN study.
32 33 The economic burden of patients with low to moderate disease activity is supported in the CERTAIN study by the substantial impairment in work productivity observed at baseline.
The innovative design features of the CERTAIN study will harness the experience of an existing network of dedicated U.S. physicians and sites to better evaluate the comparative effectiveness of biologic DMARDs.
In the CERTAIN study of RA patients with mostly MDA, addition of CZP, compared with addition of placebo, to non-biologic DMARDs led to significantly higher rates of sustained remission or LDA as assessed by CDAI (almost two-thirds of patients) and other scores.
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For the purposes of the analysis, certain study designs were treated in the following way.
This may be bolstered by providing information about the rationale for certain study designs, and highlighting the ethical assessments that clinical trials currently undertake to be approved.
By lowering the package into certain study areas, scientists will help preserve Antarctica's pristine environment.
It is based on the understanding that certain study designs are more likely to be affected by bias than others.
Because the 54% head injury DVT proportion reported by Geerts and colleagues is at odds with the current review, certain study features are worth elucidating [ 3].
For more information on the misinterpretation of certain study results, consult Byrnes' article below on vegetarian myths.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com