Therefore the categories of development, collagen and transport genes were similarly prominent in lists of genes changing among all growth plate zones, but the specific genes belonging to these gene lists were not the same in the different comparisons.
In the category of cardiovascular development, GO terms such as appendage development, cardiac atrium development and cardiac septum development were enriched in RA+ CMs while cardiac ventricle development, ventricular septum formation and heart trabecular formation were enriched in CT+ CMs (Supplementary Table S2).
As shown in Figure 7a, the five highest-ranking processes in the category of 'physiological system development and functions' were associated with development, including organ development, embryonic development, tissue development, and nervous system development.
Pathway analyses revealed that the miRNA cluster on 14q32.31 was mostly associated with the category of organismal growth and development pathway, and the miRNA cluster on 9q22 associated with cancer pathway.
On the other hand, we expected to identify known developmental genes responsible for the formation of protoperithecial reproductive structures, but the number of genes significantly differentially expressed involved in the functional category of development was very low.
A total of 328 genes were organized into 10 annotation clusters that all fit within the broad category of "Development" (top eight clusters are shown in Figure 4A).
Thirteen genes in the category of "Nervous system development" exhibited reduced expression in the IKAP-DR strain.
Other important molecular determinants of axon, dendrite and synapse growth included genes that were up-regulated in Glud1 Tg mice and are listed under the category of Nervous system development in Table 1.
18 genes in deletion CNVs and 18 genes (Additional file 1: Table S6 and Figure S2) in duplication CNVs in the category of "Cardiovascular System Development and Function" were identified as novel CHD candidate genes through mouse embryonic expression pattern analysis and Ingenuity Pathway Analysis (IPA) analysis (for details see Additional file 1).
According to this classification, kappa coefficients for agreement between factors for job satisfaction and job incentives for less highly trained laboratory professionals were almost perfect for the categories of professional development, appreciation from management, and vacation/time off.
