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One of the breakthroughs was the preferential localization of evolutionary breakpoints in regions enriched in repetitive sequences (segmental duplications, telomeres and centromeres).
One of the breakthroughs was the realization that the major function of α1-antitrypsin (AT) is inhibition of neutrophil elastase and, when circulating levels of AT are reduced, this serine proteinase can destroy the connective tissue matrix of the lung, causing emphysema (Silverman and Sandhaus, 2009).
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Not all of the breakthroughs are winners.
"Four years ago, all the breakthroughs were on the horizon," he said.
The road is long, and the breakthroughs are few.
He said the breakthrough was more psychological than political.
The breakthrough was simple in creation but brilliant in execution.
The breakthrough was the DTAG, engineered in 1999 at the Woods Hole Oceanographic Institution in Massachusetts.
The breakthrough was the invention of the star's on-screen (and, supposedly, off-) personality.
For months some ministers had been saying the breakthrough was imminent.
The breakthrough was doing that on a surface that would conduct electricity.
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