Sentence examples for the brain owing from inspiring English sources

Enzyme replacement therapy is not effective for the brain, owing to the lack of transport of the enzyme across the blood brain barrier (BBB).

Although neurological complications in patients with CRT deficiency would be caused mainly by the lack of CT transport in neuronal cells, the dysfunction of CRT may also lead to an increase in GAA in the brain, owing to the lack of CRT-mediated GAA efflux transport across the BCSFB.

The high efficacy of alectinib for ALK+ CNS metastases is considered to be due to its high penetration to the brain as well as poor efflux from the brain, owing to experimental results demonstrating that alectinib might not be transported by P-glycoprotein (P-gp) efflux protein, a key protein for blood-brain barrier (BBB) penetration [ 26].

DOI: http://dx.doi.org/10.7554/eLife.03476.001 The hippocampus is one of the most easily recognizable structures in the brain owing to its characteristic seahorse-like shape.

Within these innovative technologies, phase-change memory device has been commonly regarded as the most promising candidate to imitate the biological brain, owing to its excellent scalability, fast switching speed, and low energy consumption.

We demonstrate that local field potential slow-waves and correlated multiunit activity propagate as complex three-dimensional plumes of neuronal activity through the avian brain, owing to its non-laminar, nuclear neuronal cytoarchitecture.

Temozolomide shows good CNS penetration, and uptake into human gliomas was higher than the surrounding normal brain, owing to breakdown of the BBB and possibly tumour-induced angiogenesis (Rosso et al, 2009).

Peptide and protein therapeutics are generally excluded from transport from blood to brain, owing to the negligible permeability of these drugs to the brain capillary endothelial wall, which makes up the blood brain barrier (BBB) in vivo.

Local mass effect: shifting of the brain structures owing to the TLN nidus.

Much of what is currently known about the mechanisms and effects of visual spatial attention in the brain is owed to advances in modern electrophysiological and hemodynamic imaging techniques (e.g. Kanwisher & Wojciulik, 2000; Luck et al., 2000).

In order to address whether the effects of aldoaa and kif22 LOF were due directly to changes in expression within the brain, or secondarily, owing to effects on other tissues, shRNAs targeting these genes were expressed in the zebrafish brain.